Synthesis of novel β-aminocyclobutanecarboxylic acid derivatives by a solvent-free aza-Michael addition and subsequent ring closure.

نویسندگان

  • Tamara Meiresonne
  • Sven Mangelinckx
  • Norbert De Kimpe
چکیده

Novel β-aminocyclobutanecarboxylic acid derivatives were prepared via a sequential solvent-free aza-Michael addition of benzophenone imine across 3-halopropylidenemalonates and base-induced ring closure. These highly substituted cyclobutanedicarboxylic acid derivatives were subjected to a reactivity study which demonstrated the tendency of these donor-acceptor substituted four-membered rings to be converted into their corresponding ring-opened products.

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عنوان ژورنال:
  • Organic & biomolecular chemistry

دوره 9 20  شماره 

صفحات  -

تاریخ انتشار 2011